Death of SSRIs, Birth of Atypical Antipsychotics

At the blog The Last Psychiatrist the author makes a chilling suggestion. Not that antidepressants aren’t very effective — that seems to be a given at this point. But that drug companies are gearing up for the next phase — touting the antidepressant qualities of the atypical antipsychotics, a powerful and expensive new class of drugs known for their challenging side effects.

So here is some of the press published lately suggesting that antidepressants are about effective as placebo. From what I gather, this is actually new press for old data.

Antidepressant drugs don’t work — official study from the U.K. Independent. Two brief excerpts, italics added:

Professor Kirsch said: “Given these results, there seems to be little reason to prescribe antidepressant medication to any but the most severely depressed patients, unless alternative treatments have failed to provide a benefit. This study raises serious issues that need to be addressed surrounding drug licensing and how drug trial data is reported.”

Alternative treatments for depression, such as counselling or physical exercise , should be tried first, Professor Kirsch said. The pharmaceutical companies had withheld data that was available to the licensing authorities so that doctors and patients did not understand the true efficacy, or lack of it, of the drugs.

At Clinical Psychology and Psychiatry another look at the Kirsch et al findings.

Study doubts effectiveness of antidepressant drugs from Reuters.

Recent editorial in the American Journal of Psychiatry suggests that antidepressants are ineffective for those suffering with bipolar disorder.

Another article accessed at the Public Library of Science. Here’s the conclusion of this one:

Drug–placebo differences in antidepressant efficacy increase as a function of baseline severity, but are relatively small even for severely depressed patients. The relationship between initial severity and antidepressant efficacy is attributable to decreased responsiveness to placebo among very severely depressed patients, rather than to increased responsiveness to medication.

Kalea Chapman, Psy.D.


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Clinical Psychologist practicing in the Los Feliz neighborhood of Los Angeles, California.

One thought on “Death of SSRIs, Birth of Atypical Antipsychotics”

  1. SSRI’s like Paxil (Seroxat) are extremely dangerous , Bob Fiddaman is a Seroxat patient campaigner and he has been blogging about the Seroxat scandal for some years. Recently GSK (manufacturers of Seroxat – GlaxoSmithKline) have used threatening and intimidating tactics to try and suppress his voice.

    I am calling all mental health campaigners to highlight this on their blogs if they can.


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